Collagen synthesis in rat skin and ileum fibroblasts is affected differently by diabetes-related factors
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چکیده
منابع مشابه
Collagen synthesis by human fibroblasts
We have examined the combined effects of transforming growth factor-fl (TGF-,8), serum and y-interferon (y-IFN) on collagen synthesis by fibroblasts and compared the response of fibroblast subpopulations to TGF-,6. Human diploid fibroblasts were treated with TGF-/J alone and with serum or y-IFN. Cells were labelled with radioactive amino acids, and collagen production was measured as collagenas...
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The purpose of this study was to examine regulation of collagen synthesis in human colon fibroblasts and compare the results from colon fibroblasts with those obtained in fibroblasts from human skin. The effects of interleukin-1 beta, tumour necrosis factor alpha, interferon gamma, transforming growth factor-beta, dexamethasone, and the calcium ionophore A23187 were investigated. All compounds ...
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INTRODUCTION Skin aging may occur as a result of increased free radicals in the body. Vitamin E, the major chain-breaking antioxidant, prevents propagation of oxidative stress, especially in biological membranes. In this study, the molecular mechanism of tocotrienol-rich fraction (TRF) in preventing oxidative stress-induced skin aging was evaluated by determining the rate of total collagen synt...
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Human skin fibroblasts in in vitro culture secrete over fifty proteins into the culture medium [l]. Exported proteins include the glycoproteins, fibronectin, laminin and the collagens, all of which are involved in the composition of the extracellular cell matrix. Information is limited as to the quantities of material secreted by cultured cells during growth. Jones et al. [2] found when rat hea...
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Fibroblasts were cultured on top of or at the bottom of hydrated collagen lattices. Shortly after initially interacting with the collagen lattices, fibroblasts appeared to attach to individual collagen fibrils and in many cases cell processes were found wrapped around clusters of collagen fibrils. Tension generated by cells during spreading resulted in proximal collagen fibrils becoming aligned...
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ژورنال
عنوان ژورنال: International Journal of Experimental Pathology
سال: 2002
ISSN: 0959-9673
DOI: 10.1046/j.1365-2613.1998.t01-1-780407.x